Nowadays, more consumers read and research the information found on packaging labels including ingredient listings. 2. Available for Android and iOS devices. This liquid chromatography method is … Weng, and A. Ariffin, Butylated hydroxytoluene analogs: synthesis and evaluation of their multipotent antioxidant activities, Molecules, 17, 7645-7665 (2012). 10. R.S. Company Video. W.A. See our feature article on BHT. Long-term use studies have substantiated the overall safety and efficacy of BHT.7 In skin permeation studies, it was demonstrated that BHT has the ability to penetrate the skin; however, the amount absorbed does not appear to pass through the top layer of the skin, and it has been determined to be safe for use in cosmetics.3 It was also concluded that application of BHT to the skin does not produce appreciable systemic levels of the molecule, and it does not result in widespread irritation, sensitization, or photosensitization. People also use it as medicine. It may be … 7. A large review from 2002 concluded that BHT is safe for use on the skin in cosmetics. Intake of butylated hydroxyanisole and butylated hydroxytoluene and stomach cancer risk: results from analyses in the Netherlands Cohort Study. Shlian DM, Goldstone J. It inhibits the degradation of fats and oils through its antioxidant action and prevents rancidity. Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives. U.S. Food & Drug Administration, Select Committee on GRAS Substances (SCOGS) Opinion: Butylated Hydroxytoluene (BHT). Med Hypotheses 1987;23:39-42.. View abstract. TrustSEAL Verified. 5. It is produced by the reaction of p-cresol with isobutylene and sulfuric acid.1 The key function of BHT is that of a stabilizer. In fact, a major manufacturer of cereals volunteered to remove BHT from its cereals due to negative concerns of consumers.4 Based on toxicological studies it was concluded that BHT may produce toxicity in high oral doses and can cause adverse effects in some organs using animal models.5,6, Although there are some concerns about BHT, scientific research maintains that when used at low concentrations BHT is safe. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Olestra and trans-fatty acids (trans fats) are oil based substances which are artificially created substances. Comuth, L.M. Maas, F. ten Hoor, P.T. Bridges, Hepatic responses to the administration of high doses of BHT to the rat: their relevance to hepatocarcinogenicity, Food Chem. Butylated hydroxytoluene, commonly known as BHT, is an organic compound that is used in the food, cosmetic, and pharmaceutical industry as an antioxidant.

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