Odour=> strong diffusive sweet floral musk powerful clean macrocylic musk Sweet and musky odor of good tenacity 156 comparable to that of many related products but much inferior to the tenacity of the modern macrocyclic Lactone type Musks. As a persistent and bioaccumulative toxic chemical, Galaxolide pollution will simply get worse over time as we continue to use it. Galaxolide is the trade name from International Flavors & Fragrances Inc. (IFF) for the fragrance material with CAS Registry Number 1222-05-5 and CAS chemical name cyclopenta(g)-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-. Together with Hedione , Methyl Ionone Gamma , and Iso E Super , in roughly equal proportions, it is a key component of the so-called “Grojsman accord” – called her “hug me” accord by the perfumer herself: it is one of the most influential in modern perfumery. [20], Extensive investigations into the presence of galaxolide in biomonitoring studies,[13][21] have been completed and evaluated by various regulatory authorities. Odour. Galaxolide is a synthetic musk, a commonly used fragrance ingredient found in household products. In 2010, the state of Oregon added galaxolide to its Priority Persistent Pollutants (P3) list. 114 W Pine St – PO Box 8743 United Kingdom Patent: 991,146. Levels of Galaxolide in Great Lakes water, sediment and fish will continue to rise due to accumulating contamination from wastewater that enters the lakes. The EU published the final report for this study in 2008[7] and concluded that for all human health and environmental endpoints, "There is at present no need for further information and/or testing and no need for risk reduction measures". Galaxolide is a synthetic musk, a commonly used fragrance ingredient found in household products. 2007. As application product formulations vary widely this information is only a general guide. This Priority List was the 4th list compiled by the EU of high volume substances that were to be evaluated by the Member States’ Competent Authorities, as part of the requirements of EU Council regulation 793/93 “On the Evaluation and Control of the risk of existing substances”. Odour=> strong diffusive sweet floral musk powerful clean macrocylic musk Sweet and musky odor of good tenacity 156 comparable to that of many related products but much inferior to the tenacity of the modern macrocyclic Lactone type Musks Used in these perfume types but not limited to them. 41, No. Galaxolide is slightly sweet and floral with a powdery, fresh, clean scent similar to opening a warm tumble dryer or hanging out clean bed sheets. [2], Given its lack of bioaccumulation and toxicity, the EU determined that galaxolide does not meet the criteria for being a substance classified as Persistent, Bioaccumulative and Toxic to the environment (PBT). [4], The GreenScreen® also noted a moderate human health hazard for endocrine disruption. Historic legislation was just signed into law in California that requires disclosure of ingredients used in institutional and household cleaning products. Benchmark 1 is assigned to chemicals of highest concern whose use is recommended to be avoided. [3], It was first synthesized in 1965 and its discovery was mainly due to the work by Beets on the osmophoric group of the polycyclic musks, where they tried to improve existing synthetic musks by making them more stable and hydrophobic [4], Galaxolide has become the key synthetic musk ingredient belonging to the polycyclic musk group as defined by the International Fragrance Association (IFRA). This means that Galaxolide may interfere with hormones and other chemical signals in the body which can result in developmental, reproductive, metabolic, brain, and behavior problems. Vol. It combines well with other musks and is often used in combinations. One study found Galaxolide in 81% of water samples from Great Lakes tributaries that run through urban areas. Vol. The isomers are (4R,7R), (4R,7S), (4S,7S) and (4S, 7R). Learn more. 47, pp: 4821-4825. PerfumersWorld BBA IFF KAO IFF TAKA The SCHER opinions for galaxolide are available for the environment,[14] for human health[24] and for human health though indirect exposure.[25]. [6], Galaxolide has a measured bioconcentration factor (BCF) in fish in a range of 600-1600 and a log octanol-water partition coefficient (Log Kow) of around 5.5 (5.3 – 5.9). For example, the use of Galaxolide by European product manufacturers has been on the decline for years. Manufacturers still using Galaxolide simply must follow this lead. At room temperature, it occurs as a highly viscous liquid. The GreenScreen® assigned Galaxolide a score of Benchmark 1. Pear, Rice, Since fragrance ingredients are not required to be disclosed on a product label or website, consumers will have to ask a manufacturer if their products contain Galaxolide in order to avoid the chemical. [15], 4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[, InChI=1S/C18H26O/c1-11-9-19-10-13-7-15-16(8-14(11)13)18(5,6)12(2)17(15,3)4/h7-8,11-12H,9-10H2,1-6H3, InChI=1/C18H26O/c1-11-9-19-10-13-7-15-16(8-14(11)13)18(5,6)12(2)17(15,3)4/h7-8,11-12H,9-10H2,1-6H3, Except where otherwise noted, data are given for materials in their. [10], Galaxolide degrades in the environment to primary degradants with log Kow <4 and further to more hydrophilic products with Log Kow of <1. Chemosphere, 1996, 33(10), pages 2033-2043. Habanolide. Galaxolide was first synthesized in 1965, and used in the late 1960s in some fabric softeners and detergents. Vol 113. Galaxolide is widely used by cleaning and personal care product companies and can be found in many products including surface cleaners, laundry products, air fresheners, cosmetics and perfumes. Specifically, the GreenScreen® assigned the Benchmark 1 score due to Galaxolide’s high persistent, bioaccumulative and aquatic toxicity properties. [6] A study of new mothers found Galaxolide present in 97% of breast milk samples.[7]. Galaxolide (trade name; also known as Abbalide, Pearlide, Astrolide, Musk 50, Polarlide; chemical name 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8,-hexamethyl-cyclopenta[g]benzopyran or HHCB) is a synthetic musk with a clean sweet musky floral woody odor used in fragrances. Solutions: Blends-well-with=> +Decanal Topnote Pusher +Cyclamen Aldehyde +Nonanal Topnote Pusher +Lilial +Benzyl Salicylate Balsams, Musk 50 : Pearlide : Abbalide : Hexahydro-4,6,6,7,8,8-hexamethyl cyclopenta- -2-benzopyran : Galaxolide : Hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5(4H)-one : 9-Oxo-cedrane : Abbalide : Galaxolide 50 : Musk 50 : Pearlide : Shangralide (base) : Mosfarone 50 1,3,4,6,7,8-Hexahydro-4,6,6,7,5,8-hexamethyl cyclopenta gamma-2-benzopyran : Galaxolide : Women’s Voices for the Earth commissioned a GreenScreen® for Safer Chemicals assessment of Galaxolide to determine its hazard level. [22] The SCCNFP stated that "...HHCB [galaxolide] can be safely used as a fragrance ingredient in cosmetic products without any restriction for its use. [6] Hutter H. et.al. A GreenScreen® takes into account data on 18 different health and environmental endpoints to determine a hazard score. Its melting point is -20 °C and its boiling point is estimated to be 330 °C based on a boiling point of 160 °C at 4hPa. (2009) Synthetic musks in blood of healthy young adults: Relationship to cosmetics use. [2] Baldwin AK, Corsi SR, DeCicco LA, Lenaker PL, Lutz MA, Sullivan DJ and Richards KD. GreenScreen® for Safer Chemicals is an internationally recognized tool for comparing and assessing the hazards of chemicals in order to identify those of high concern and evaluate safer alternatives. Vol.40, No. The trend towards increasing Galaxolide contamination in the Great Lakes can be reversed. womensvoices@womensvoices.org. A limited list of products which contain Galaxolide can be found here: [Products Containing Galaxolide]. EU-SCCNFP safety evaluation for HHCB in cosmetics: EU-SCHER Opinion on HHCB safety for human health. January 2005. Galaxolide was first synthesized in 1965, and used in the late 1960s in some fabric softeners and detergents. Visit our press room or contact our communications director. 11, pp: 3815-3820. DOWNLOAD and view the complete GreenScreen® assessment of Galaxolide. EU Scientific Committee on Consumer Safety; Opinion on Fragrance Allergens: Rimkus, G.G. What California’s Ban on Toxic Chemicals in Cosmetics Means for Salon Worker Health, Interview with Bria Gadsden of Love Your Menses, We Need to Talk About the Term ‘Feminine Hygiene’, Toxic exposure risks lurk in menstrual products, California Is About To Become the Second State Requiring Ingredient Transparency in Period Products, California lawmakers approve ingredient disclosure bill for menstrual products. When household products containing Galaxolide are used, the long-lasting fragrance chemical ends up in wastewater, which survives wastewater treatment plants to end up in our waterways and eventually in the Great Lakes. [7] Reiner JL, Wong CM, Arcaro KF and Kannan K. (2007) Synthetic Musk Fragrances in Human Milk from the United States. [18], Galaxolide has been reported to be found in human biomonitoring studies and its presence in human tissue has been evaluated by several scientific authorities. 1031 33rd Street In a study of lake sediment in Lake Erie found galaxolide levels to be doubling every 8–16 years. 2004. Environmental Science and Technology. The outcome of all those studies is that galaxolide is safe for use in consumer products. [1] High concentrations were also incorporated in fine fragrances. Galaxolide may also be known as hexamethylindanopyran under the International Nomenclature of Cosmetic Ingredients (INCI). [4] Peck AM, Linebaugh EK, Hornbuckle KC. Science of the Total Environment. This means that Galaxolide does not break down easily in the environment, builds up over time, and is highly toxic to fish and other aquatic creatures. (2006) Synthetic musk fragrances in Lake Erie and Lake Ontario sediment cores. Galaxolide is strong diffusive sweet floral musk clean macrocylic soap-powder macrocyclic lactone musks all-florals muguet laundry soap. Perfume-Uses=> All-types Florals Muguet Laundry Soap Musk Comfort And Softlan Up To 40% Tresor 20% … [2], Galaxolide is classified as R50/53 under the EU DSD and as H410 under EU CLP classification rules. Women’s Voices for the Earth [7][22][23], In 2002, The Scientific Committee on Cosmetics and Non-Food Products (SCCNFP), the expert scientific board that advises the European Commission on human health issues, reviewed the human safety of galaxolide, when used in cosmetic products, and issued a final opinion on 17 September 2002. [9] The EPA's PBT Profiler also finds Galaxolide to exceed the EPA's criteria as a PBT. and M. Wolf, Polycyclic musk fragrances in human adipose tissue and human milk. Legislation and regulations vary widely and change with time so it is your duty to check this. Those participants that used scented lotions and perfumes had significantly higher levels of Galaxolide than those that did not. The odour and uses of Galaxolide A number of studies have detected Galaxolide contamination in the Great Lakes, in the water, air and sediment. Full testing by both perfumers- flavorists and end users is the only proven method to ensuring a perfume or flavours safety- strength- suitability- stability and success. at the Posner Center September 15 2006. Disinfectant chemicals called quaternary ammonium compounds “quats”, commonly found in wipes are especially problematic. Vol. 554-555, 42-52. All physical chemical data are derived from the galaxolide REACH registration dossier: Heeringa L.G.

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